Description

1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-,Ethyl Ester,(1S)- is a chiral, non-racemic synthetic intermediate of significant importance in advanced organic synthesis. This compound matters as a key building block for the construction of complex nitrogen-containing heterocycles, particularly in the pharmaceutical sector. It is needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of potential drug candidates, particularly those targeting neurological and cardiovascular systems.
• Asymmetric Synthesis: Used as a starting material or intermediate in stereoselective reactions to introduce the tetrahydroisoquinoline scaffold.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, or plant growth regulators with specific chiral activity.
• Ligand and Catalyst Development: Utilized in the preparation of novel chiral ligands for metal-catalyzed asymmetric transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance molecules, dyes, or other high-value specialty chemicals.
• Academic and R&D: A valuable compound for methodological studies in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-,Ethyl Ester,(1S)-
CAS No.	288839-72-5
Molecular Formula	C₁₃H₁₇NO₂
Molecular Weight	219.28 g/mol
Synonyms	(1S)-1,2,3,4-Tetrahydro-1-isoquinolineacetic acid ethyl ester; (S)-Ethyl 1,2,3,4-tetrahydro-1-isoquinolineacetate; (S)-1,2,3,4-Tetrahydroisoquinoline-1-acetic acid ethyl ester; (S)-Tic ethyl ester; Ethyl (S)-1,2,3,4-tetrahydroisoquinoline-1-acetate; (S)-1-Carbethoxymethyl-1,2,3,4-tetrahydroisoquinoline; (S)-1,2,3,4-Tetrahydro-1-isoquinolineacetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. For this chiral intermediate, quality is assured through comprehensive analytical methods including chiral HPLC to confirm enantiomeric excess (ee) and standard purity assays. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for identity, purity, and chiral purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.