Description

(2R,3R,4R,5S)-1,1,2,3,4,5,6,6-Octadeuteriohexane-1,2,3,4,5,6-Hexol CAS NO 287962-59-8 is a deuterium-labeled isotopologue of D-mannitol, a key sugar alcohol. This high-purity, stable isotope-labeled compound is essential for advanced analytical and research applications where precise molecular tracking is required. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as metabolic pathway studies and as an internal standard for quantitative mass spectrometry.

Application

• Internal Standard for Quantitative Analysis: Used in LC-MS, GC-MS, and NMR for accurate quantification of D-mannitol in complex biological matrices.
• Metabolic Pathway Tracing: Enables detailed studies of carbohydrate metabolism, absorption, and distribution in pharmacokinetic and biomedical research.
• Pharmaceutical Research & Development: Serves as a labeled precursor or tracer in the development and validation of new drug formulations and delivery systems.
• Stable Isotope Labeling Studies: Critical for mechanistic studies in enzymology and biochemistry to elucidate reaction pathways without kinetic isotope effects typical of heavier isotopes.
• Quality Control & Method Development: Employed in analytical laboratories to develop and validate highly specific and sensitive assay methods.
• Biomarker Research: Facilitates research into physiological and pathological processes involving polyol pathways.

Basic Information

Product Name	(2R,3R,4R,5S)-1,1,2,3,4,5,6,6-Octadeuteriohexane-1,2,3,4,5,6-Hexol
CAS No.	287962-59-8
Molecular Formula	C6D8H6O6
Molecular Weight	188.20 g/mol
Synonyms	D-Mannitol-d8; [1,1,2,3,4,5,6,6-2H8]-D-Mannitol; Deuterated D-Mannitol; Mannitol-d8; Hexadeutero-D-mannitol; (2R,3R,4R,5S)-Hexane-1,2,3,4,5,6-hexol-1,1,2,3,4,5,6,6-d8; 1,2,3,4,5,6-Hexadeutero-D-mannitol
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced and controlled under a strict quality management system. Each batch undergoes comprehensive analysis to ensure high chemical purity and isotopic enrichment. Certificates of Analysis (COA) are provided, detailing key parameters such as assay (by NMR or HPLC), isotopic purity (D-content), and identification. We support research and compliance needs for GMP, ISO, and other regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC or NMR)	≥ 98.0% (chemical purity)
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.