Description

4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid is a stable isotope-labeled analog of 4-hydroxybenzoic acid, where all six carbon atoms are replaced with the carbon-13 isotope. This high-purity labeled compound is essential for advanced analytical applications requiring precise internal standards and metabolic pathway tracing. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in quantitative mass spectrometry, pharmacokinetic studies, and metabolic research.

Application

• Quantitative Mass Spectrometry (MS): Serves as a critical internal standard for the accurate quantification of 4-hydroxybenzoic acid and related metabolites in complex biological matrices.
• Metabolic Pathway Analysis: Used as a tracer in in vitro and in vivo studies to elucidate the biosynthesis and degradation pathways of phenolic compounds.
• Pharmaceutical R&D: Enables precise drug metabolism and pharmacokinetics (DMPK) studies for compounds metabolized through benzoic acid pathways.
• Environmental and Food Analysis: Acts as a reference standard in LC-MS/MS methods for detecting parabens, preservatives, and phenolic pollutants.
• Stable Isotope Labeling: A key building block for the synthesis of more complex carbon-13 labeled molecules for research.

Basic Information

Product Name	4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid
CAS No.	287399-29-5
Molecular Formula	13C6H6O3
Molecular Weight	144.06 (based on 13C)
Synonyms	p-Hydroxybenzoic-13C6 Acid; 4-Hydroxybenzoic Acid (Ring-13C6); PHBA-13C6; Benzoic-13C6 Acid, 4-Hydroxy-; [13C6]-4-Hydroxybenzoic Acid; 4-Carboxyphenol-13C6; Paraben Metabolite-13C6; 287399-29-5 (CAS)
EINECS	Contact for details

Quality Control

Every batch of our 4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.