Description

Acetyl-1-13C-L-Carnitine Hydrochloride is a stable isotope-labeled derivative of L-carnitine, where the acetyl group is enriched with carbon-13 at the 1-position. This specific labeling is critical for advanced metabolic research and pharmaceutical development, enabling precise tracking and quantification in complex biological systems. It is an essential tool for researchers and manufacturers in the pharmaceutical, diagnostic, and nutraceutical industries who require high-purity, isotopically defined compounds for pharmacokinetic studies, biomarker discovery, and quality control of labeled APIs.

Application

• Isotope-Labeled Internal Standards: For accurate quantification of L-carnitine and its metabolites in biological samples (plasma, urine, tissue) using LC-MS/MS and GC-MS.
• Metabolic Pathway Tracing: To study fatty acid oxidation, mitochondrial function, and energy metabolism in preclinical and clinical research.
• Pharmaceutical Reference Standard: As a certified reference material (CRM) for the quality control and validation of assays for acetyl-L-carnitine-based drugs and supplements.
• Diagnostic Agent Development: In the research and production of advanced diagnostic kits and probes for metabolic disorders.
• Nutraceutical Research: For conducting bioavailability, bioequivalence, and mechanism-of-action studies on acetyl-L-carnitine formulations.
• Stable Isotope Probing (SIP): Used in microbial ecology and environmental science to trace the metabolism of carnitine derivatives in complex systems.

Basic Information

Product Name	Acetyl-1-13C-L-Carnitine Hydrochloride
CAS No.	287389-45-1
Molecular Formula	C913CH18NO4 • HCl
Molecular Weight	240.69 g/mol (for 13C1 isotopologue)
Synonyms	(2R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, 2-(acetyl-1-13C)oxy-, chloride, inner salt; L-Carnitine O-acetate-1-13C hydrochloride; ALCAR-1-13C HCl; Acetyl-L-carnitine-1-13C hydrochloride; (R)-3-Acetoxy-4-(trimethylammonio)butyrate-1-13C hydrochloride; Levacecarnine-1-13C hydrochloride; Vitamin Bt derivative-1-13C
EINECS	Contact for details

Quality Control

Every batch of our Acetyl-1-13C-L-Carnitine Hydrochloride is produced and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical assay, NMR and MS for isotopic enrichment verification, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) are provided with each shipment, detailing all specification results, including the exact 13C atom percent enrichment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
13C Isotopic Enrichment	≥ 99 atom % 13C
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.