Description

Methyl 6-(1-Boc-Piperidin-4-Yloxy)Indole-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, particularly those targeting neurological and oncological pathways. It is essential for research institutions, CROs, and pharmaceutical companies engaged in the development of novel therapeutic agents and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly in medicinal chemistry programs.
• Protease Inhibitor Research: Used in the development and study of protease inhibitors due to its indole-carboxylate scaffold and protected amine functionality.
• Kinase Inhibitor Synthesis: Serves as a building block for creating novel kinase inhibitors, a major class of targeted cancer therapies.
• Peptidomimetic Chemistry: Employed in the design and construction of peptidomimetics, which mimic peptides for enhanced stability and bioavailability.
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme function and cellular signaling pathways.
• Custom Synthesis & Scale-Up: Supplied for custom synthesis projects, from milligram-scale research to kilogram-scale process development for clinical trials.

Basic Information

Product Name	Methyl 6-(1-Boc-Piperidin-4-Yloxy)Indole-2-Carboxylate
CAS No.	287389-12-2
Molecular Formula	C21H28N2O5
Molecular Weight	388.46 g/mol
Synonyms	6-[(1-tert-Butoxycarbonyl-4-piperidinyl)oxy]-1H-indole-2-carboxylic acid methyl ester; Methyl 6-[(1-(tert-Butoxycarbonyl)-4-piperidinyl)oxy]-1H-indole-2-carboxylate; 1-Boc-4-(2-Methoxycarbonylindol-6-yloxy)piperidine; 6-(1-Boc-Piperidin-4-Yloxy)Indole-2-Carboxylic Acid Methyl Ester; Boc-Pip-O-Indole-2-COOMe; CAS 287389-12-2
EINECS	Contact for details

Quality Control

Our Methyl 6-(1-Boc-Piperidin-4-Yloxy)Indole-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of preclinical and early-phase clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.