Description

L-Aspartic Acid-1-13C, n-Fmoc Derivative, n-(9-Fluorenylmethoxycarbonyl)-L-Aspartic Acid-1-13C is a stable isotope-labeled, Fmoc-protected derivative of the amino acid aspartic acid, specifically enriched with carbon-13 at the 1-position. This compound is essential for advanced research in peptide synthesis and metabolic studies, where precise isotopic tracing is required. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies specializing in proteomics, isotope labeling, and the development of novel peptide-based therapeutics.

Application

• Isotope-Labeled Peptide Synthesis: As a key building block for the solid-phase and solution-phase synthesis of 13C-labeled peptides for NMR spectroscopy and mass spectrometry studies.
• Metabolic Pathway Tracing: Used in biochemical research to track the incorporation and fate of aspartic acid in metabolic pathways using 13C-NMR or LC-MS.
• Proteomics Research: Enables the preparation of internal standards for the accurate quantification of proteins and peptides via isotope dilution mass spectrometry.
• Pharmaceutical Development: Serves as a critical intermediate in the research and development of isotope-labeled drug candidates and diagnostic agents.
• Bioconjugation and Labeling: The Fmoc-protected amino acid is used to introduce a 13C label at a specific site into larger biomolecules for structural and functional analysis.
• Academic Research: Fundamental studies in organic chemistry, biochemistry, and medicinal chemistry investigating amino acid chemistry and protein dynamics.

Basic Information

Product Name	L-Aspartic Acid-1-13C, n-Fmoc Derivative, n-(9-Fluorenylmethoxycarbonyl)-L-Aspartic Acid-1-13C
CAS No.	286460-77-3
Molecular Formula	C19H17NO6 (with 13C at position 1)
Molecular Weight	~355.34 g/mol (13C adjusted)
Synonyms	Fmoc-L-Aspartic Acid-1-13C; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic-1-13C acid; Nα-Fmoc-L-aspartic acid-1-13C; (2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}butanedioic-1-13C acid; Fmoc-Asp(13C)-OH; Fmoc-L-Asp(13C1)-OH; N-Fmoc-L-aspartic acid-1-13C; 9-Fluorenylmethyloxycarbonyl-L-aspartic acid-1-13C
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid-1-13C, n-Fmoc Derivative is manufactured under strict quality systems to ensure high chemical and isotopic purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chiral purity, and chemical purity. We adhere to rigorous in-house specifications and can provide material suitable for sensitive analytical and synthetic procedures. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.