Description

Estrone-2,4,16,16-D4 3-Sulfate is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This compound is specifically designed for use in quantitative mass spectrometry, enabling precise and accurate measurement of endogenous estrone sulfate levels in complex biological matrices. It is an essential tool for researchers and quality control laboratories in pharmaceutical development, clinical research, and endocrinology studies requiring the highest level of analytical rigor.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the LC-MS/MS quantification of estrone sulfate in plasma, serum, and tissue samples.
• Clinical Research & Diagnostics: Enables precise hormone level monitoring in studies related to menopause, hormone-dependent cancers, and endocrine disorders.
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies during the development of steroid-based therapeutics.
• Metabolomics & Biomarker Discovery: Facilitates accurate profiling of steroid metabolites in large-scale metabolomic studies.
• Reference Standard: Acts as a certified reference material (CRM) for method development, validation, and laboratory accreditation.
• Doping Control Analysis: Supports anti-doping laboratories in the sensitive detection of prohibited endogenous steroids.

Basic Information

Product Name	Estrone-2,4,16,16-D4 3-Sulfate
CAS No.	285979-80-8
Molecular Formula	C18H18D4O5S
Molecular Weight	354.45 g/mol
Synonyms	Estrone-2,4,16,16-d4 3-Sulfate; Estrone-d4 Sulfate; [2,4,16,16-2H4]-Estrone 3-Sulfate; 3-Hydroxyestra-1,3,5(10)-trien-17-one-2,4,16,16-d4 3-Sulfate; Deuterated Estrone Sulfate; E1S-d4; Estrone Sulfate-d4; E1-d4 Sulfate
EINECS	Contact for details

Quality Control

Every batch of Estrone-2,4,16,16-D4 3-Sulfate is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and high-resolution mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data for identity, purity (HPLC), isotopic enrichment, and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant in the container. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.