Description

Choline-1,1,2,2-D4 Bromide is a deuterium-labeled analog of choline bromide, a key quaternary ammonium salt. This stable isotope-labeled compound is essential for advanced analytical research, providing an internal standard for precise quantification and metabolic pathway tracing. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications in mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical reference compound for the accurate quantification of choline and its metabolites in complex biological matrices using LC-MS/MS and GC-MS.
• Metabolic Pathway Tracing: Used in pharmacokinetic and pharmacodynamic studies to track the absorption, distribution, metabolism, and excretion (ADME) of choline-containing compounds.
• NMR Spectroscopy Studies: Acts as a deuterated probe for investigating molecular structure, dynamics, and interactions in solution-state NMR.
• Pharmaceutical R&D: Employed in the development and validation of analytical methods for drugs and nutraceuticals related to choline metabolism.
• Biochemical Research: Facilitates studies on lipid metabolism, neurotransmission (as a precursor to acetylcholine), and methyl-group transfer reactions.
• Quality Control & Reference Material: Provides a certified reference material for ensuring accuracy and compliance in analytical laboratories.

Basic Information

Product Name	Choline-1,1,2,2-D4 Bromide
CAS No.	285979-69-3
Molecular Formula	C5H10D4BrNO
Molecular Weight	188.09 g/mol
Synonyms	(2-Hydroxyethyl)trimethylammonium-1,1,2,2-d4 Bromide; (2-Hydroxyethyl-d4)trimethylammonium Bromide; Choline-d4 Bromide; Deuterocholine Bromide; (β-Hydroxyethyl)trimethylammonium-d4 Bromide; N,N,N-Trimethylethanolammonium-1,1,2,2-d4 Bromide; 2-Hydroxy-N,N,N-trimethylethanaminium-1,1,2,2-d4 Bromide
EINECS	Contact for details

Quality Control

Our Choline-1,1,2,2-D4 Bromide is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by NMR or titration), isotopic purity (D-enrichment), and identification. We adhere to relevant standards for high-purity research chemicals, and custom purity grades are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (by Titration)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.