Description

1,3-Propanediol-D8 is a high-purity, deuterium-labeled isotopologue of 1,3-propanediol, serving as a critical internal standard and tracer in advanced analytical and research applications. Its value lies in providing unmatched precision for quantitative analysis using techniques like mass spectrometry and NMR, where it compensates for matrix effects and instrumental variability. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and chemical synthesis sectors who require definitive analytical accuracy.

Application

• Internal Standard for Mass Spectrometry (MS): Used for the precise quantification of 1,3-propanediol and related compounds in complex biological and chemical matrices.
• Metabolic Pathway Tracing: Acts as a stable isotopic tracer in biochemical and pharmacokinetic studies to elucidate metabolic fluxes and pathways.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a deuterated solvent or reference standard for structural analysis and method development.
• Pharmaceutical Impurity Profiling: Enables accurate identification and quantification of process-related impurities and degradants in drug substances and products.
• Biomarker Research: Facilitates the development and validation of sensitive assays for disease biomarkers in clinical research.
• Chemical Synthesis Research: Employed in mechanistic studies to track the fate of atoms during catalytic and synthetic processes.
• Quality Control & Method Validation: Critical for developing and validating GMP/GLP-compliant analytical methods in regulated industries.

Basic Information

Product Name	1,3-Propanediol-D8
CAS No.	285978-25-8
Molecular Formula	C₃D₈O₂
Molecular Weight	92.15 g/mol
Synonyms	1,3-Propanediol-d8; [1,1,2,2,3,3,3-d7, 1-d]-1,3-Propanediol; Deuteronol PD-d8; Trimethylene Glycol-d8; 1,3-Dihydroxypropane-d8; Propane-1,3-diol-d8; PDO-d8; Bio-PDO (d8)
EINECS	Contact for details

Quality Control

Every batch of our 1,3-Propanediol-D8 is manufactured and tested under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (D atom%), chemical purity by HPLC/GC, and specific tests for residual solvents and moisture. Our quality commitment aligns with the standards expected for research and analytical use in GMP/GLP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to reference spectrum
Isotopic Purity (D atom%)	≥ 98% (by MS)
Chemical Purity (GC / HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.