Description

4-Aminophenol-D7 is a high-purity, deuterium-labeled analog of 4-aminophenol, a key intermediate in pharmaceutical synthesis and analytical chemistry. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring precise and accurate measurements in complex matrices. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and analytical instrument manufacturing sectors.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of 4-aminophenol and related metabolites in pharmacokinetic, toxicological, and bioanalytical studies.
• Pharmaceutical Impurity Profiling: Used in method development and validation to track and quantify potential genotoxic impurities (PGIs) in active pharmaceutical ingredients (APIs) and finished drug products.
• Metabolite Tracing: Enables detailed metabolic pathway studies in drug discovery and development, providing insights into drug metabolism and disposition.
• Environmental and Food Safety Analysis: Supports the detection and measurement of aminophenol contaminants in environmental samples and food products.
• Chemical Reference Standard: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring regulatory compliance (e.g., FDA, ICH guidelines).
• Stable Isotope Labeling in Synthesis: Used in the synthesis of more complex deuterated molecules for research purposes.

Basic Information

Product Name	4-Aminophenol-D7
CAS No.	285132-88-9
Molecular Formula	C6D7NO
Molecular Weight	114.16 g/mol
Synonyms	4-Amino-D7-phenol; p-Aminophenol-D7; 4-Hydroxyaniline-D7; Paraminophenol-D7; 1-Amino-4-hydroxybenzene-D7; Rodinal-D7 (historical); Deuterated 4-Aminophenol; [2,3,5,6-D4, 1,4-D2(N)]-4-Aminophenol
EINECS	Contact for details

Quality Control

Our 4-Aminophenol-D7 is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity, and results of all specified tests. We support compliance with ICH Q3B, USP, and EP guidelines for impurities and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, keep under an inert gas (argon or nitrogen) in a freezer (-20°C). Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.