Description

Diethyl-D10-Amine Hydrochloride is a deuterium-labeled analog of diethylamine hydrochloride, where all ten hydrogen atoms are replaced by the stable isotope deuterium. This high isotopic purity makes it an essential internal standard and tracer in quantitative mass spectrometry and NMR spectroscopy, ensuring analytical accuracy and reliability. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for drug metabolism studies, environmental fate analysis, and the development of deuterated active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS: Critical for accurate quantification of diethylamine and related compounds in bioanalytical and pharmacokinetic studies.
• Metabolic Pathway Tracing: Used in pharmaceutical R&D to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Deuterated API Synthesis: Serves as a key building block for synthesizing deuterium-labeled active pharmaceutical ingredients, which can offer improved metabolic stability.
• NMR Spectroscopy Solvent & Reagent: Provides a non-interfering deuterium signal for structural elucidation and reaction monitoring.
• Environmental Analysis: Employed as a tracer to study the environmental fate and degradation pathways of amine-based chemicals.
• Chemical Reaction Mechanism Studies: Utilized to investigate kinetic isotope effects and detailed reaction mechanisms in organic synthesis.

Basic Information

Product Name	Diethyl-D10-Amine Hydrochloride
CAS No.	285132-87-8
Molecular Formula	C4D10N·HCl or C4H10NCl (deuterated)
Molecular Weight	Approx. 117.64 g/mol (deuterated form)
Synonyms	Deuterated Diethylamine Hydrochloride; Diethylamine-d10 Hydrochloride; Diethylamine-1,1,2,2,2-d5 Hydrochloride (common notation); (C2D5)2NH·HCl; N,N-Diethyl-d10-amine hydrochloride; Perdeuterodiethylamine hydrochloride; DEA-d10 HCl; Diethylamine (ethyl-d5) hydrochloride
EINECS	Contact for details

Quality Control

Our Diethyl-D10-Amine Hydrochloride is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity for sensitive analytical applications. Each batch is characterized by NMR, Mass Spectrometry, and HPLC to confirm deuterium incorporation and chemical identity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (typically >98 atom % D), chemical purity, and residual solvent levels is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (NMR/MS)	≥98 atom % D
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.