Description

1,4-Butane-D8-Diamine 2Hcl is a deuterium-labeled analog of putrescine dihydrochloride, where eight hydrogen atoms are replaced with deuterium. This high-purity, isotopically labeled compound is critical for applications requiring precise internal standards in mass spectrometry and advanced research into metabolic pathways. It is primarily utilized by analytical laboratories, pharmaceutical R&D teams, and academic researchers in life sciences for quantitative analysis and tracer studies.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the accurate quantification of putrescine and related polyamines in complex biological matrices.
• Metabolic Pathway Research: Used as a deuterium tracer to study the biosynthesis, catabolism, and physiological roles of polyamines in cell culture and in vivo models.
• Pharmaceutical Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies during drug discovery, particularly for compounds targeting polyamine metabolism.
• Clinical Diagnostics: Facilitates the development of robust mass spectrometry-based assays for diagnosing disorders related to polyamine imbalance.
• Biochemical Research: Essential for enzymatic assays and studies investigating the interaction of polyamines with nucleic acids and proteins.
• Nutraceutical & Food Analysis: Enables precise measurement of natural polyamine content in food products and dietary supplements for quality control.

Basic Information

Product Name	1,4-Butane-D8-Diamine 2Hcl
CAS No.	284665-22-1
Molecular Formula	C4D8H4N2·2HCl
Molecular Weight	209.16 g/mol
Synonyms	Putrescine-d8 Dihydrochloride; 1,4-Diaminobutane-d8 Dihydrochloride; Tetramethylenediamine-d8 Dihydrochloride; Butane-1,4-diamine-d8 Dihydrochloride; [2H8]-Putrescine Dihydrochloride; Deuterated Putrescine 2HCl; 1,4-Butanediamine-d8 Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of 1,4-Butane-D8-Diamine 2Hcl is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical documentation. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters including assay, isotopic enrichment, and impurity profile as determined by NMR, HPLC, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.