Description

Dl-Methionine-D3 CAS NO 284665-20-9 is a stable isotope-labeled analog of the essential amino acid methionine, where three hydrogen atoms are replaced by deuterium. This compound is a critical tool in metabolic research and pharmaceutical development, enabling precise tracking and quantification of methionine pathways. It is primarily required by research institutions, pharmaceutical companies, and analytical laboratories engaged in pharmacokinetic studies, proteomics, and stable isotope labeling mass spectrometry (SIL-MS).

Application

• Stable Isotope Labeling Mass Spectrometry (SIL-MS): Used as an internal standard for the accurate quantification of methionine and its metabolites in complex biological samples.
• Pharmacokinetic and Metabolic Studies: Enables the tracing of methionine absorption, distribution, metabolism, and excretion (ADME) in drug development.
• Proteomics Research: Facilitates protein turnover studies and the identification of newly synthesized proteins in cell culture and animal models.
• Clinical Diagnostics: Serves as a reference standard in assays for inborn errors of metabolism related to sulfur amino acid pathways.
• Nutritional Research: Investigates methionine utilization, requirements, and metabolism in various physiological and disease states.
• Pharmaceutical Impurity Profiling: Acts as a reference marker in the analysis and quality control of methionine-containing drug substances.

Basic Information

Product Name	Dl-Methionine-D3
CAS No.	284665-20-9
Molecular Formula	C5H8D3NO2S
Molecular Weight	152.23 g/mol (for deuterated form)
Synonyms	(±)-2-Amino-4-(methyl-d3-sulfanyl)butanoic acid; DL-Methionine-methyl-d3; Methionine (methyl-d3); Racemic Methionine-d3; 2-Amino-4-((methyl-d3)thio)butyric acid; (RS)-Methionine-d3; Methionine-d3 (DL); Deuterated DL-Methionine
EINECS	Contact for details

Quality Control

Our Dl-Methionine-D3 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D3), chemical purity, and specific analytical results. We support research and regulatory needs with reliable, batch-traceable materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.