Description

D-Methionine-D3 (S-Methyl-D3) is a stable isotope-labeled analog of the essential amino acid D-Methionine, specifically deuterated at the S-methyl group. This high-purity compound is critical for applications requiring precise metabolic and pharmacokinetic studies where standard methionine would interfere with detection and quantification. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in advanced mass spectrometry, NMR spectroscopy, and tracer studies for drug development and biochemical research.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference in LC-MS and GC-MS analyses for accurate measurement of methionine and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used as a stable isotope tracer in pharmacokinetic (PK) and pharmacodynamic (PD) studies to investigate drug metabolism, protein synthesis, and one-carbon cycle dynamics.
• NMR Spectroscopy: Provides a non-radioactive probe for structural and mechanistic studies in biochemistry and medicinal chemistry, leveraging the distinct nuclear magnetic resonance properties of deuterium.
• Pharmaceutical R&D: Essential in the development and validation of bioanalytical methods for new drug entities, ensuring regulatory compliance for assays.
• Nutritional and Biomedical Research: Facilitates studies on amino acid turnover, metabolic disorders, and the role of methionine in health and disease states.

Basic Information

Product Name	D-Methionine-D3 (S-Methyl-D3)
CAS No.	284665-18-5
Molecular Formula	C5H8D3NO2S
Molecular Weight	152.23 g/mol (for deuterated form)
Synonyms	(2R)-2-Amino-4-(methyl-d3)sulfanylbutanoic acid; D-Methionine-methyl-d3; (R)-2-Amino-4-((trideuteriomethyl)sulfanyl)butyric acid; Deuterated D-Methionine; D-Met-d3; S-Methyl-D3-L-methionine (inverse stereochemistry); Stable Isotope Labeled D-Methionine
EINECS	Contact for details

Quality Control

Our D-Methionine-D3 is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, which is paramount for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D, atom %), chemical purity (by HPLC), and chiral purity. We support research and development requiring compliance with various pharmacopeial standards, and custom specifications can be developed to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.