Description

n-Acetyl-L-Aspartic Acid-D3 is a stable isotope-labeled derivative of the endogenous amino acid derivative N-Acetyl-L-aspartic acid (NAA). This compound is specifically deuterated, making it an essential internal standard for precise quantitative analysis in mass spectrometry-based research. It is primarily utilized in pharmaceutical R&D, clinical diagnostics, and neuroscience studies where accurate measurement of NAA levels is critical. The product is supplied with guaranteed isotopic purity and chemical stability for reliable analytical results.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a quantitative reference standard in the measurement of endogenous N-Acetyl-L-aspartic acid in biological matrices like plasma, serum, and cerebrospinal fluid.
• Metabolomics Research: Enables accurate tracking and quantification of NAA in metabolic pathway studies and biomarker discovery.
• Neurological Disorder Research: Critical for studies investigating conditions such as Canavan disease, brain tumors, and multiple sclerosis, where NAA levels are a key biomarker.
• Pharmaceutical Development: Supports drug metabolism and pharmacokinetic (DMPK) studies for compounds targeting the central nervous system.
• Clinical Diagnostics: Employed in the development and validation of in-vitro diagnostic (IVD) assays for neurological conditions.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike-in standard for high-precision, definitive methods in clinical chemistry and reference laboratories.

Basic Information

Product Name	n-Acetyl-L-Aspartic Acid-D3
CAS No.	284665-15-2
Molecular Formula	C6H6D3NO5
Molecular Weight	177.14 g/mol
Synonyms	(2S)-2-Acetamido-3-(1,1,2,2,2-pentadeuterio-1-carboxyethyl)butanedioic acid; N-Acetyl-L-aspartic-2,3,3-d3 acid; N-Acetyl-L-aspartic acid-d3; NAA-d3; N-Acetylaspartic acid-d3; L-N-Acetylaspartic acid-d3; (S)-2-Acetamidosuccinic-2,3,3-d3 acid; Ac-Asp-OH-d3
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-L-Aspartic Acid-D3 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) that include data for isotopic purity (D-enrichment), chemical purity, and identity confirmation. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference material in regulated environments. Specifications are designed to align with the needs of analytical and research laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.