Description

Glycine-2,2-D2-n-Fmoc is a deuterium-labeled, Fmoc-protected derivative of the amino acid glycine, specifically designed for advanced research and development applications. This compound is critical for studies requiring isotopic labeling, such as metabolic pathway tracing, protein structure elucidation, and pharmacokinetic analysis. It is an essential building block for pharmaceutical researchers, peptide chemists, and analytical scientists working in drug discovery, proteomics, and stable isotope labeling.

Application

• Peptide Synthesis: As a deuterium-labeled precursor in solid-phase and solution-phase peptide synthesis for creating isotopically labeled peptides.
• Metabolic Research: Used as a tracer in mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies to investigate metabolic pathways and fluxes.
• Proteomics & Biomarker Discovery: Enables quantitative proteomic analysis through techniques like SILAC (Stable Isotope Labeling by Amino acids in Cell culture).
• Pharmaceutical Development: Serves as a key intermediate in the synthesis of deuterated drug candidates for improved metabolic stability and pharmacokinetic profiles.
• Analytical Reference Standard: Provides a high-purity standard for the calibration and validation of analytical methods (HPLC, LC-MS) in quality control laboratories.
• Structural Biology: Aids in protein NMR spectroscopy by simplifying complex spectra, facilitating the determination of protein structure and dynamics.

Basic Information

Product Name	Glycine-2,2-D2-n-Fmoc
CAS No.	284665-11-8
Molecular Formula	C17H13D2NO4
Molecular Weight	299.31 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,2-dideuterioglycine; Fmoc-glycine-d2; Fmoc-Gly(D2)-OH; (2,2-Dideuterio-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino})acetic Acid; N-Fmoc-2,2-dideutero-glycine; 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-2,2-dideuteroacetic Acid; Fmoc-Gly(d2); Deuterated Fmoc-Glycine
EINECS	Contact for details

Quality Control

Our Glycine-2,2-D2-n-Fmoc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and deuterium enrichment analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), isotopic enrichment, and other critical parameters is provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.