Description

Dl-Phenyl-D5-Alanine CAS NO 284664-89-7 is a deuterium-labeled isotopologue of the amino acid phenylalanine, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is a critical tool in advanced analytical research, enabling precise quantification and metabolic pathway tracing. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry, NMR spectroscopy, and drug metabolism studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous phenylalanine and related metabolites.
• Metabolic Pathway Tracing: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• NMR Spectroscopy Studies: Acts as a probe in nuclear magnetic resonance (NMR) to elucidate protein structure, dynamics, and ligand-binding interactions without signal interference from protons.
• Biochemical Research: Employed in enzymatic assays and in vitro studies to investigate amino acid metabolism and related disorders.
• Pharmaceutical Development: Integral in the development and validation of bioanalytical methods for new drug entities, ensuring regulatory compliance.
• Nutritional Science Research: Used in stable isotope feeding studies to investigate protein synthesis and amino acid turnover in clinical and nutritional research.

Basic Information

Product Name	Dl-Phenyl-D5-Alanine
CAS No.	284664-89-7
Molecular Formula	C9H6D5NO2
Molecular Weight	171.20 g/mol (approx.)
Synonyms	DL-Phenylalanine-d5; (RS)-2-Amino-3-(2,3,4,5,6-pentadeuteriophenyl)propanoic acid; Phenylalanine-2,3,4,5,6-d5; (rac)-Phenylalanine-d5; 3-Phenyl-d5-alanine; DL-α-Amino-β-(pentadeuteriophenyl)propionic acid; Phenyl-D5-alanine
EINECS	Contact for details

Quality Control

Our Dl-Phenyl-D5-Alanine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and isotopic enrichment, typically meeting standards for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as assay purity (by HPLC), isotopic purity (by MS), and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.