Description

Dl-Lysine-4,4,5,5-D4 2Hcl is a deuterium-labeled isotopologue of the essential amino acid lysine, where four hydrogen atoms are replaced with deuterium at the 4 and 5 positions. This stable isotope-labeled compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by scientists and manufacturers in pharmaceutical development, metabolic research, and analytical chemistry for use as an internal standard in mass spectrometry.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for accurate quantification in LC-MS and GC-MS analysis of lysine and related metabolites in biological samples.
• Metabolic Pathway Tracing: Used in stable isotope labeling studies to investigate protein metabolism, nutrient utilization, and metabolic flux analysis.
• Pharmaceutical Research & Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies for novel therapeutics targeting amino acid pathways.
• Proteomics and Biomarker Discovery: Facilitates precise relative and absolute quantification in complex proteomic analyses.
• Nutritional Science Research: Aids in studying lysine requirements, absorption, and whole-body protein turnover in clinical and animal studies.
• Synthesis of Labeled Compounds: Serves as a key building block for the synthesis of more complex deuterium-labeled peptides or biochemicals.

Basic Information

Product Name	Dl-Lysine-4,4,5,5-D4 2Hcl
CAS No.	284664-88-6
Molecular Formula	C6H10D4Cl2N2O2
Molecular Weight	223.15 g/mol (for unlabeled C6H14N2O2•2HCl); Contact for exact labeled MW.
Synonyms	DL-Lysine-4,4,5,5-d4 dihydrochloride; (4,4,5,5-2H4)-DL-Lysine dihydrochloride; Lysine-d4 (racemic) dihydrochloride; 2,6-Diaminohexanoic-4,4,5,5-d4 acid dihydrochloride; (±)-Lysine-4,4,5,5-d4 2HCl; H-DL-Lys(4,4,5,5-d4)-OH•2HCl; (RS)-2,6-Diaminocaproic-4,4,5,5-d4 acid dihydrochloride
EINECS	Contact for details

Quality Control

Our stable isotope-labeled compounds are produced and analyzed under stringent conditions to ensure high chemical and isotopic purity, which is paramount for research integrity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, isotopic enrichment, and purity by HPLC. We adhere to rigorous in-house quality standards designed for research and analytical applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Assay)	≥ 95% (by titration)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.