Description

Dl-Lysine-3,3,4,4,5,5,6,6-D8 2Hcl is a deuterium-labeled derivative of the essential amino acid lysine, specifically designed for use as an internal standard in quantitative mass spectrometry. This high-purity compound is critical for ensuring analytical accuracy and reproducibility in research and development. It is primarily utilized by scientists and quality control professionals in the pharmaceutical, biotechnology, and academic research sectors for advanced metabolic studies, proteomics, and pharmacokinetic analysis.

Application

• Quantitative Mass Spectrometry (MS): Serves as a stable isotope-labeled internal standard for the precise quantification of lysine and related metabolites in complex biological matrices.
• Metabolomics & Proteomics Research: Enables accurate tracking and measurement of amino acid turnover, protein synthesis rates, and metabolic pathway flux analysis.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in the development and validation of bioanalytical methods for studying the absorption, distribution, metabolism, and excretion (ADME) of new drug candidates.
• Clinical Diagnostics: Facilitates the development of highly specific and sensitive assays for detecting inborn errors of metabolism or nutritional status markers.
• Biochemical Research: Acts as a tracer in enzymatic studies and investigations into amino acid transport and utilization at the cellular level.
• Quality Control Reference Standard: Provides a certified reference material for calibrating analytical instruments and verifying method accuracy in pharmaceutical quality control laboratories.

Basic Information

Product Name	Dl-Lysine-3,3,4,4,5,5,6,6-D8 2Hcl
CAS No.	284664-87-5
Molecular Formula	C6H6D8Cl2N2O2
Molecular Weight	231.18 g/mol (for deuterated form)
Synonyms	DL-Lysine-d8 dihydrochloride; (3,3,4,4,5,5,6,6-D8)-DL-Lysine dihydrochloride; Lysine-d8 2HCl; Hexadeutero-DL-lysine dihydrochloride; 2,6-Diaminohexanoic-3,3,4,4,5,5,6,6-d8 acid dihydrochloride; (RS)-2,6-Diaminocaproic-3,3,4,4,5,5,6,6-d8 acid dihydrochloride; DL-Lysine-D8 hydrochloride; Deuterated lysine internal standard
EINECS	Contact for details

Quality Control

Our Dl-Lysine-3,3,4,4,5,5,6,6-D8 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and related substances are provided to ensure full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric humidity. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.