Description

Creatine-(Methyl-D3) Monohydrate is a stable isotope-labeled analog of creatine monohydrate, where three hydrogen atoms on the methyl group are replaced by deuterium (D). This compound is essential for advanced research and analytical applications requiring precise metabolic tracing. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and analytical laboratories focused on sports science, metabolic disorders, and pharmacokinetic studies.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical reference standard in LC-MS and GC-MS analysis for the accurate quantification of endogenous creatine in biological samples.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate creatine metabolism, synthesis, and transport mechanisms in vivo.
• Pharmaceutical Research: Employed in the development and validation of bioanalytical methods for drugs and supplements related to muscle metabolism.
• Clinical Diagnostics: Aids in research for diagnosing and monitoring conditions like creatine deficiency syndromes and muscular dystrophies.
• Sports Science Studies: Facilitates research into creatine supplementation, absorption, and its effects on athletic performance and recovery.
• Stable Isotope-Labeled Compound Synthesis: Acts as a key intermediate or precursor for synthesizing more complex deuterated molecules for research.

Basic Information

Product Name	Creatine-(Methyl-D3) Monohydrate
CAS No.	284664-86-4
Molecular Formula	C4H6D3N3O2 • H2O
Molecular Weight	152.15 g/mol
Synonyms	Creatine-(methyl-d3) Monohydrate; (N-Methyl-d3)guanidinoacetic Acid Monohydrate; (N-Methyl-d3)glycocyamine Monohydrate; N-(Aminoiminomethyl)-N-methyl-d3-glycine Monohydrate; N-Methyl-d3-N-(aminoiminomethyl)glycine Monohydrate; Deuterated Creatine Monohydrate; [Methyl-d3]Creatine Monohydrate; Creatine-d3 Monohydrate
EINECS	Contact for details

Quality Control

Our Creatine-(Methyl-D3) Monohydrate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm isotopic purity, chemical purity, and identity. Certificates of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical assay, and impurity profiles are provided. We adhere to cGMP principles for research-grade materials to ensure consistent quality and reliable performance in sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Isotopic Purity	≥ 98 atom % D (by 1H NMR or MS)
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 12.0% (Theoretical for monohydrate)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.