Description

Creatine-D3 Hydrate is a high-purity, isotopically labeled derivative of creatine, a vital organic compound in cellular energy metabolism. This product is essential for research and development applications requiring precise metabolic tracing and quantification. It is primarily utilized by analytical laboratories, pharmaceutical R&D departments, and academic institutions focused on sports science, metabolic disorders, and pharmacokinetic studies.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as an internal standard for the accurate quantification of endogenous creatine levels in biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Research: Used as a tracer to study creatine and phosphocreatine kinetics, turnover rates, and metabolic fluxes in muscle, brain, and cardiac tissues.
• Pharmaceutical Development: Employed in the development and validation of bioanalytical methods for drugs targeting energy metabolism or muscle-related conditions.
• Clinical Research: Facilitates studies on disorders of creatine metabolism, such as guanidinoacetate methyltransferase (GAMT) deficiency or creatine transporter (SLC6A8) deficiency.
• Sports Science & Nutrition: Applied in research investigating creatine supplementation, muscle performance, recovery, and body composition.
• Quality Control & Reference Standard: Acts as a certified reference material for calibrating laboratory equipment and ensuring the accuracy of diagnostic assays.

Basic Information

Product Name	Creatine-D3 Hydrate
CAS No.	284664-83-1
Molecular Formula	C4H6D3N3O2 • xH2O
Molecular Weight	134.13 (Anhydrous Free Acid Basis)
Synonyms	Creatine(methyl-d3); N-Methyl-N-(aminoiminomethyl)-d3-glycine; (αS)-α-(Carboxymethylamino)-N-(methyl-d3)guanidine; 2-[Carbamimidoyl(methyl-d3)amino]acetic acid; Guanidinoacetic Acid-d3 (Methyl-d3); Isotopically Labeled Creatine; Creatine Internal Standard; Deuterated Creatine
EINECS	Contact for details

Quality Control

Our Creatine-D3 Hydrate is manufactured under strict quality management systems. Each batch is characterized and tested to ensure high chemical purity and isotopic enrichment, meeting the stringent requirements for research and analytical applications. Comprehensive Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), residual solvent content, and other critical parameters are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.