Description

Tetramethyl-D12-Ammonium Bromide is a fully deuterated quaternary ammonium salt, serving as a critical isotopically labeled standard and reagent. Its value lies in providing a non-exchangeable deuterium label for precise analytical and mechanistic studies, eliminating background interference from protons. This compound is essential for researchers and manufacturers in pharmaceutical development, NMR spectroscopy, and mass spectrometry, where tracking molecular pathways and ensuring accurate quantification are paramount.

Application

• Internal Standard for Mass Spectrometry (MS): Used for the accurate quantification of quaternary ammonium compounds and related analytes in LC-MS and GC-MS methods.
• NMR Spectroscopy Solvent & Reagent: Acts as a deuterium source and a shift reagent in nuclear magnetic resonance studies, providing a clean spectral background.
• Pharmaceutical Research & Metabolism Studies: Employed as a stable isotopic tracer to investigate drug metabolism, pharmacokinetics, and biochemical pathways.
• Chemical Synthesis Intermediate: Serves as a labeled building block for the synthesis of more complex deuterated molecules in organic and medicinal chemistry.
• Analytical Method Development: Crucial for developing and validating sensitive analytical methods in regulatory and quality control environments.
• Material Science Research: Used in studies involving ionic liquids, surfactants, and phase-transfer catalysts where labeled analogs are required.

Basic Information

Item	Detail
Product Name	Tetramethyl-D12-Ammonium Bromide
CAS No.	284474-82-4
Molecular Formula	C4D12BrN
Molecular Weight	172.10 g/mol
Synonyms	Ammonium, tetrakis(trideuteriomethyl)-, bromide; Perdeuterated Tetramethylammonium Bromide; Tetramethyl-d12-ammonium Bromide; TMA-d12 Bromide; Tetramethylammonium-d12 Bromide; N,N,N-Trimethyl-d9-methanaminium-d3 Bromide; d12-TMABr
EINECS	Contact for details

Quality Control

Every batch of Tetramethyl-D12-Ammonium Bromide is produced and tested under strict quality management protocols to ensure the highest isotopic and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (D atom %), chemical purity, and identity confirmation. Our quality systems support compliance with the rigorous standards required for research, analytical, and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Deuterium Content (NMR/MS)	≥ 98 atom % D
Assay (HPLC/Titration)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.