Description

1,6-Diaminohexane-D12 Dihydrochloride is a deuterated derivative of hexamethylenediamine dihydrochloride, where all twelve hydrogen atoms on the carbon backbone are replaced with deuterium. This high isotopic purity makes it an essential internal standard and tracer in quantitative mass spectrometry and NMR spectroscopy, ensuring analytical accuracy and reliability. It is primarily required by researchers and quality control laboratories in the pharmaceutical, agrochemical, and advanced materials sectors for metabolic studies, pharmacokinetics, and method development.

Application

• Internal Standard for LC-MS/MS: Used as a stable, non-interfering reference compound for the precise quantification of hexamethylenediamine and related compounds in complex biological and environmental matrices.
• Metabolic Pathway Tracing: Employed in pharmaceutical R&D to study the absorption, distribution, metabolism, and excretion (ADME) of polyamine-based drugs and biomolecules.
• NMR Spectroscopy: Serves as a deuterated reagent or shift reference in nuclear magnetic resonance studies due to its defined isotopic labeling.
• Polymer Chemistry Research: Acts as a labeled monomer or chain extender in the synthesis of deuterated nylons (e.g., Nylon-6,6) for studying polymer dynamics, morphology, and degradation.
• Forensic and Environmental Analysis: Utilized as a calibration standard in methods detecting amine-based contaminants or degradation products.
• Biochemical Research: Applied in studies of polyamine biochemistry and enzymology where tracking without isotopic interference is critical.

Basic Information

Product Name	1,6-Diaminohexane-D12 Dihydrochloride
CAS No.	284474-80-2
Molecular Formula	C6D12N2·2HCl
Molecular Weight	209.22 g/mol
Synonyms	Hexamethylenediamine-D12 Dihydrochloride; 1,6-Hexanediamine-D12 Dihydrochloride; Deuterated Hexamethylenediamine Dihydrochloride; D12-HMDA·2HCl; [2H12]-1,6-Diaminohexane Dihydrochloride; Perdeuterated 1,6-Diaminohexane Dihydrochloride; 1,6-Diaminoperdeuterohexane Dihydrochloride
EINECS	Contact for details

Quality Control

Our 1,6-Diaminohexane-D12 Dihydrochloride is manufactured under controlled conditions to ensure high chemical and isotopic purity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % D), chemical purity, and impurity profile. We adhere to stringent in-house quality standards suitable for analytical and research applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.