Description

4'-Chloroacetophenone-2',3',5',6'-D4 is a deuterium-labeled analog of 4'-chloroacetophenone, a valuable building block in synthetic organic chemistry. This isotopically labeled compound is essential for applications requiring precise tracking and analysis, such as in mass spectrometry and metabolic studies. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for the development of deuterated active pharmaceutical ingredients (APIs) and as an internal standard.

Application

• Pharmaceutical Research & Development: As a deuterated intermediate in the synthesis of isotopically labeled drug candidates for pharmacokinetic (PK) and metabolic stability studies.
• Analytical Chemistry: Employed as a stable isotope-labeled internal standard for the accurate quantification of 4'-chloroacetophenone and related compounds via LC-MS or GC-MS.
• Metabolite Identification: Used in tracer studies to elucidate metabolic pathways and identify drug metabolites in biological systems.
• Agrochemical Development: Serves as a precursor in the synthesis of deuterated agrochemicals for environmental fate and degradation studies.
• Material Science: A potential monomer or precursor for creating specialized polymers and advanced materials with modified properties.
• Academic Research: A key reagent in mechanistic studies and synthetic methodology development within university and institutional laboratories.

Basic Information

Product Name	4'-Chloroacetophenone-2',3',5',6'-D4
CAS No.	284474-50-6
Molecular Formula	C8H3D4ClO
Molecular Weight	156.62 g/mol (for deuterated form)
Synonyms	1-(4-Chlorophenyl)-2,3,5,6-tetradeuterioethanone; p-Chloroacetophenone-d4; 4-Chloroacetophenone-2,3,5,6-d4; 4'-Chloroacetophenone-d4; 1-(4-Chlorophenyl)ethanone-2,3,5,6-d4; Deutero-p-chloroacetophenone; 4-Chlorophenyl methyl ketone-d4
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced under strict quality protocols to ensure high isotopic purity and chemical integrity. Each batch of 4'-Chloroacetophenone-2',3',5',6'-D4 is characterized by NMR and mass spectrometry to confirm deuteration level and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles. Our quality system supports research requiring traceable and reliable isotopic standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat sources and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, NMR)	≥ 98 atom % D
Chemical Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.