Description

Dl-Proline-2-D1 CAS NO 282729-06-0 is a deuterium-labeled isotopologue of the amino acid proline, where a hydrogen atom at the 2-position is replaced by a deuterium atom. This stable isotope labeling is critical for advanced research applications requiring precise molecular tracking and analysis. This high-purity compound is essential for scientists and manufacturers in the fields of pharmaceutical research, metabolic studies, and analytical chemistry.

Application

• Pharmaceutical Research & Development: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of proline and related compounds in drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Analysis: Serves as a tracer in metabolic flux analysis to investigate the biosynthesis and degradation pathways of proline in biological systems, providing insights into cellular physiology and disease mechanisms.
• Proteomics and Biomarker Discovery: Employed in stable isotope labeling by amino acids in cell culture (SILAC) and other quantitative proteomic techniques to study protein expression, turnover, and post-translational modifications.
• NMR Spectroscopy Studies: Acts as a valuable tool in Nuclear Magnetic Resonance (NMR) spectroscopy for structural elucidation and dynamic studies of peptides, proteins, and complex molecules, leveraging the distinct magnetic properties of deuterium.
• Chemical Synthesis Intermediate: Utilized in the synthesis of deuterium-labeled peptides, peptidomimetics, and other bioactive molecules for research purposes, enhancing the stability and analytical properties of the final products.
• Quality Control & Reference Standard: Functions as a certified reference material (CRM) in analytical laboratories to ensure the accuracy, precision, and compliance of analytical methods for amino acid analysis.

Basic Information

Product Name	Dl-Proline-2-D1
CAS No.	282729-06-0
Molecular Formula	C5H8DNO2
Molecular Weight	116.15 g/mol (approx.)
Synonyms	DL-Proline-2-d1; (RS)-Proline-2-d1; (±)-Proline-2-d1; 2-Deuterio-DL-proline; Pyrrolidine-2-d1-2-carboxylic acid; DL-2-Deuteroproline; Proline-d1 (2-position); Deuterated DL-proline
EINECS	Contact for details

Quality Control

Our Dl-Proline-2-D1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and Mass Spectrometry, to confirm isotopic enrichment, chemical purity, and identity. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom purity grades and packaging are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified for high-purity grades. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.