Description

Dl-Leucine-2-D1 CAS NO 282726-23-2 is a stable isotope-labeled analog of the essential branched-chain amino acid leucine, where a deuterium atom replaces a specific hydrogen atom. This precise labeling is critical for advanced research applications requiring high sensitivity and specificity, such as metabolic pathway tracing and pharmacokinetic studies. It is an indispensable tool for pharmaceutical R&D, academic research, and analytical laboratories focused on proteomics, metabolomics, and drug discovery.

Application

• Internal Standard in Mass Spectrometry (MS): Used as a quantitative reference in LC-MS and GC-MS analyses for accurate measurement of endogenous leucine levels in biological samples.
• Metabolic Pathway Tracing: Enables the detailed study of protein synthesis, turnover, and amino acid metabolism in cell cultures, tissues, and whole organisms.
• Pharmaceutical Research: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug candidates containing leucine moieties.
• Proteomics & Biomarker Discovery: Facilitates precise relative and absolute quantification (SILAC, AQUA) of proteins in complex biological mixtures.
• Nutritional Science Research: Investigates leucine utilization, requirements, and effects on muscle protein synthesis in metabolic studies.
• NMR Spectroscopy: Serves as a deuterated probe for structural analysis and dynamic studies of proteins and peptides.

Basic Information

Product Name	Dl-Leucine-2-D1
CAS No.	282726-23-2
Molecular Formula	C6H12DNO2
Molecular Weight	132.18 g/mol (approx.)
Synonyms	(±)-2-Amino-4-methylpentanoic-2-d acid; DL-Leucine-2-d1; (RS)-Leucine-2-D1; 2-Deuterio-DL-leucine; 4-Methyl-2-deuterio-DL-norvaline; Leucine-2-d1 (racemic); Amino isobutylacetic-2-d acid (racemic); UNII-Contact for details
EINECS	Contact for details

Quality Control

Our Dl-Leucine-2-D1 is manufactured under strict quality systems to ensure the highest standards of isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for isotopic enrichment (D-content), chemical purity, and identity. We support compliance with relevant research and development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.