Description

1-Carboxymethyl-6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a sophisticated, high-purity chemical intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the development of complex pharmaceutical molecules, particularly those targeting neurological and cardiovascular pathways. It is primarily sought by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex alkaloids and isoquinoline-based drug candidates.
• Neurological Research: Used in the development of compounds for potential application in neurodegenerative disease research and treatment.
• Cardiovascular Drug Development: Serves as a building block for molecules being investigated for hypertension and other cardiovascular conditions.
• Chemical Biology & Proteomics: Employed in the design and synthesis of specialized probes and inhibitors for enzyme and receptor studies.
• Process Chemistry Optimization: Used by fine chemical manufacturers to scale up and optimize synthetic routes for commercial API production.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting exploratory medicinal chemistry programs.

Basic Information

Product Name	1-Carboxymethyl-6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	282524-92-9
Molecular Formula	C₁₈H₂₃NO₆
Molecular Weight	349.38 g/mol
Synonyms	tert-Butyl 1-carboxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline-1-acetic Acid; 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-acetic Acid tert-Butyl Ester; 1-Carboxymethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic Acid tert-Butyl Ester; BOC-DMIQAA; (1,2,3,4-Tetrahydro-6,7-dimethoxy-1-isoquinolyl)acetic Acid 1,1-Dimethylethyl Ester; 282524-92-9; tert-Butyl (6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2(1H)-yl)acetate-1-carboxylate (alternative IUPAC).
EINECS	Contact for details

Quality Control

Our production of 1-Carboxymethyl-6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester adheres to stringent quality protocols suitable for pharmaceutical R&D and cGMP intermediate applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive analytical results, including HPLC purity, NMR confirmation, and residual solvent analysis, are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. For long-term storage, consider the use of desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.