Description

(+)-cis-Tramadol (S)-(+)-Mandelate is a high-purity, single-enantiomer salt form of the centrally acting analgesic, tramadol. This specific stereoisomer is of significant interest for pharmaceutical research and development, particularly in the study of opioid receptor pharmacology and analgesic efficacy. It serves as a critical reference standard and key intermediate for researchers and manufacturers in the pharmaceutical industry who require precise chirality for their synthetic pathways or analytical methods.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control (HPLC, GC, LC-MS) in API and finished product testing.
• Active Pharmaceutical Ingredient (API) Intermediate: A chiral building block in the synthesis of enantiomerically pure tramadol and its derivatives.
• Pharmacological Research: A vital tool for in vitro and in vivo studies to investigate the stereoselective metabolism, pharmacokinetics, and receptor binding profiles of tramadol enantiomers.
• Process Development & Optimization: Employed in scaling up and optimizing synthetic routes for tramadol production under cGMP conditions.
• Regulatory Compliance & Documentation: Serves as an authentic substance for regulatory filings (e.g., FDA, EMA) to support drug applications.

Basic Information

Product Name	(+)-cis-Tramadol (S)-(+)-Mandelate
CAS No.	280565-80-2
Molecular Formula	C24H31NO5
Molecular Weight	413.51 g/mol
Synonyms	(1R,2R)-Tramadol (S)-Mandelate; (+)-(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol (S)-Mandelate; (1R,2R)-Tramadol (S)-(+)-Mandelate; cis-(+)-Tramadol (S)-Mandelate; Tramadol (1R,2R) isomer mandelate salt; (R,R)-(+)-Tramadol (S)-(+)-Mandelate
EINECS	Contact for details

Quality Control

Our (+)-cis-Tramadol (S)-(+)-Mandelate is manufactured and tested to meet the stringent requirements for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure identity, potency, and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with our rigorous internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect the integrity of the product.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.