Description

(Z)-2-(4-(4-Methoxyphenyl)Thiazol-2-Yl)-3-(Thiophen-2-Yl)Acrylonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture combining thiazole, thiophene, and acrylonitrile moieties. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and targeted drug delivery. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for synthesizing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting specific protein kinases or cellular pathways.
• Organic Light-Emitting Diode (OLED) Research: Used in the development of new electron-transport or emissive layer materials due to its conjugated system and electron-deficient acrylonitrile group.
• Agrochemical Synthesis: Acts as a precursor for creating new active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Investigated for use in organic semiconductors and non-linear optical (NLO) materials.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Fluorescent Probe Development: Its rigid, conjugated structure makes it a candidate for designing fluorescent sensors and bio-imaging agents.

Basic Information

Product Name	(Z)-2-(4-(4-Methoxyphenyl)Thiazol-2-Yl)-3-(Thiophen-2-Yl)Acrylonitrile
CAS No.	277756-76-0
Molecular Formula	C₁₇H₁₂N₂OS₂
Molecular Weight	324.42 g/mol
Synonyms	(Z)-2-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3-(thiophen-2-yl)prop-2-enenitrile; 2-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3-(2-thienyl)-2-propenenitrile, (Z)-; (2Z)-2-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3-thiophen-2-ylprop-2-enenitrile; 277756-76-0; (Z)-2-(4-(4-Methoxyphenyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile; Acrylonitrile, 2-[4-(4-methoxyphenyl)-2-thiazolyl]-3-(2-thienyl)-, (Z)-
EINECS	Contact for details

Quality Control

Every batch of (Z)-2-(4-(4-Methoxyphenyl)Thiazol-2-Yl)-3-(Thiophen-2-Yl)Acrylonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance documentation for your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.