Description

Bicyclo[3.1.0]Hexan-3-One, 4-Hydroxy-4-Methyl-1-(1-Methylethyl)-, (1S,4R,5S)- (9Ci) is a high-purity, stereochemically defined bicyclic ketone derivative, serving as a critical chiral building block and advanced pharmaceutical intermediate. Its complex, rigid molecular framework and defined stereochemistry make it invaluable for synthesizing novel compounds with specific biological activity. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-quality, structurally complex intermediates for asymmetric synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Utilized as a sophisticated chiral starting material or auxiliary in stereoselective reactions to construct complex molecular architectures.
• Agrochemical Research: Serves as a precursor in the development of novel, high-performance pesticides and herbicides with specific modes of action.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, flavors, fragrances, and other high-value-added products requiring precise stereochemical control.
• Academic & Industrial R&D: Used in medicinal chemistry and process chemistry research to explore new synthetic pathways and reaction methodologies.
• Ligand & Catalyst Development: Potential building block for creating novel chiral ligands and organocatalysts used in enantioselective transformations.

Basic Information

Product Name	Bicyclo[3.1.0]Hexan-3-One, 4-Hydroxy-4-Methyl-1-(1-Methylethyl)-, (1S,4R,5S)- (9Ci)
CAS No.	273406-45-4
Molecular Formula	C10H16O2
Molecular Weight	168.23 g/mol
Synonyms	(1S,4R,5S)-4-Hydroxy-4-methyl-1-(propan-2-yl)bicyclo[3.1.0]hexan-3-one; (1S,4R,5S)-4-Hydroxy-4-methyl-1-isopropylbicyclo[3.1.0]hexan-3-one; 4-Hydroxy-4-methyl-1-(1-methylethyl)-, (1S,4R,5S)-Bicyclo[3.1.0]hexan-3-one; (1S,4R,5S)-rel-4-Hydroxy-4-methyl-1-(1-methylethyl)bicyclo[3.1.0]hexan-3-one; Chiral Bicyclo[3.1.0]hexanone Derivative
EINECS	Contact for details

Quality Control

Every batch of our Bicyclo[3.1.0]Hexan-3-One, 4-Hydroxy-4-Methyl-1-(1-Methylethyl)-, (1S,4R,5S)- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, critical for your advanced synthesis work. Certificates of Analysis (COA) detailing specifications such as chiral purity (enantiomeric excess), chemical purity (by HPLC/GC), and residual solvents are available upon request and are aligned with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.