Description

Rac-4-Hydroxycyclohexyl Tramadol Hydrochloride is a key intermediate in the synthesis of tramadol and its related pharmaceutical compounds. This high-purity chemical building block is critical for ensuring the quality and consistency of the final active pharmaceutical ingredient (API). It is primarily utilized by pharmaceutical R&D laboratories and manufacturers engaged in the production of analgesic medications and for developing novel chemical entities.

Application

• Pharmaceutical Intermediate: Primary use as a critical synthetic precursor in the commercial and research-scale production of the analgesic Tramadol and its structural analogs.
• Analgesic Drug Development: Serves as a key building block in medicinal chemistry for the research and development of new centrally-acting pain relievers.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and quality assurance (QA) laboratories for method development and validation.
• Process Chemistry & Optimization: Employed in scaling up synthetic routes and optimizing manufacturing processes for opioid-based pharmaceuticals.
• Academic & Institutional Research: Utilized in universities and research institutes for pharmacological studies and investigating structure-activity relationships (SAR).

Basic Information

Product Name	Rac-4-Hydroxycyclohexyl Tramadol Hydrochloride
CAS No.	273398-39-3
Molecular Formula	C16H25NO2·HCl
Molecular Weight	299.84 g/mol (Hydrochloride salt)
Synonyms	(±)-cis-2-[(Dimethylamino)methyl]-1-(4-hydroxycyclohexyl)cyclohexanol hydrochloride; 1-(4-Hydroxycyclohexyl)-2-[(dimethylamino)methyl]cyclohexanol hydrochloride (racemic); Tramadol Impurity; Tramadol Related Compound; Tramadol Intermediate; UNII-9I0KCA2672; (±)-Tramadol metabolite M1 precursor
EINECS	Contact for details

Quality Control

Our Rac-4-Hydroxycyclohexyl Tramadol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.