Description

1-(2-[4-(6-Fluoro-1H-Indol-3-Yl)-3,6-Dihydro-2H-Pyridin-1-Yl]-Ethyl)-3-Isopropyl-6-Methanesulfonyl-3,4-Dihydro-1H-Benzo[1,2,6]Thiadiazine 2,2-Dioxide is a sophisticated heterocyclic organic compound featuring a complex molecular architecture that combines indole, pyridine, and benzothiadiazine dioxide moieties. This compound is of significant interest as a key pharmaceutical intermediate or active pharmaceutical ingredient (API) precursor in advanced medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel drug candidates, especially those targeting complex biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• API Development: Employed in the process development and scale-up of potential Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Biochemical Tool Compound: May be utilized in biochemical assays and as a pharmacological probe to study specific enzyme or receptor interactions in academic and industrial research settings.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Item	Details
Product Name	1-(2-[4-(6-Fluoro-1H-Indol-3-Yl)-3,6-Dihydro-2H-Pyridin-1-Yl]-Ethyl)-3-Isopropyl-6-Methanesulfonyl-3,4-Dihydro-1H-Benzo[1,2,6]Thiadiazine 2,2-Dioxide
CAS No.	271780-64-4
Molecular Formula	C26H30FN5O4S2
Molecular Weight	551.68 g/mol
Synonyms	271780-64-4; 1-(2-{4-[(6-Fluoro-1H-indol-3-yl)]-3,6-dihydro-2H-pyridin-1-yl}ethyl)-3-(propan-2-yl)-6-(methylsulfonyl)-3,4-dihydro-2H-1,2,6-benzothiadiazine 1,1-dioxide; 6-Fluoro-3-(1-{2-[3-isopropyl-6-(methylsulfonyl)-1,1-dioxido-3,4-dihydro-2H-1,2,6-benzothiadiazin-1-yl]ethyl}-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole; Benzo[1,2,6]thiadiazine, 1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-, 2,2-dioxide
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, and residual solvents. We support development projects requiring compliance with ICH guidelines and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is likely light-sensitive and may be hygroscopic; therefore, containers should be kept sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.