Description

(S)-2-Tetrahydroisoquinoline Acetic Acid Hydrochloride CAS NO 270082-22-9 is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its primary value lies in its role as a key building block for the development of novel, optically active pharmaceutical compounds and fine chemicals. This product is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable source of a specific enantiomer for their synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to induce chirality in target molecules.
• Medicinal Chemistry Research: Serves as a core scaffold for the design and synthesis of new chemical entities (NCEs) in drug discovery programs.
• Agrochemical Development: Employed in the synthesis of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances that require enantiomerically pure components.
• Academic & Contract Research: A valuable reagent for universities and contract research organizations (CROs) conducting studies in synthetic methodology and bioactivity.

Basic Information

Product Name	(S)-2-Tetrahydroisoquinoline Acetic Acid Hydrochloride
CAS No.	270082-22-9
Molecular Formula	C₁₁H₁₄ClNO₂
Molecular Weight	227.69 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-2-acetic acid hydrochloride; (S)-2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)acetic acid hydrochloride; (S)-Tic-OH.HCl; (S)-2-Carboxymethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; (S)-2-(1,2,3,4-Tetrahydro-2-isoquinolinyl)acetic acid HCl; (S)-2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)ethanoic acid hydrochloride; (2S)-2-(3,4-Dihydro-1H-isoquinolin-2-yl)acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-Tetrahydroisoquinoline Acetic Acid Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.