Description

1,2-Benzenediol, 4-Fluoro-5-[(1S)-1-Hydroxy-2-(Methylamino)Ethyl]- (9Ci) is a specialized fluorinated catechol derivative with a chiral amino alcohol side chain, representing a high-value synthetic intermediate. This compound is critical for research and development in advanced pharmaceutical synthesis, particularly for creating novel active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular systems.
• Research Chemical: Used in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new synthetic methodologies.
• Precursor for Adrenergic Receptor Ligands: Its structural motif is valuable for creating analogs of compounds that interact with adrenergic receptors.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce fluorinated catechol moieties into complex molecular architectures.
• Asymmetric Synthesis: Utilizes the chiral (S)-configured center for the production of enantiomerically pure compounds.

Basic Information

Product Name	1,2-Benzenediol, 4-Fluoro-5-[(1S)-1-Hydroxy-2-(Methylamino)Ethyl]- (9Ci)
CAS No.	269742-65-6
Molecular Formula	C9H12FNO3
Molecular Weight	201.20 g/mol
Synonyms	4-Fluoro-5-[(1S)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol; (S)-4-Fluoro-5-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol; 4-Fluoro-5-[(1S)-1-hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; A fluorinated derivative of norepinephrine; Chiral fluorocatechol derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and impurity profiles. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep the container tightly sealed when not in use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.