Description

tert-Butyl ((1H-Indol-5-Yl)Methyl)Carbamate is a protected amine derivative, specifically a carbamate of 5-(aminomethyl)indole, serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on indole-based active pharmaceutical ingredients (APIs), peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting neurological and oncological pathways.
• Peptidomimetic Research: Used to incorporate indole scaffolds into peptide backbones to enhance stability and biological activity.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for primary amines in multi-step synthetic sequences.
• Agrochemical Synthesis: Serves as a precursor in the development of new crop protection agents and plant growth regulators.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploring new chemical spaces.
• Scale-up & Process Chemistry: Suitable for optimization and kilogram-scale production under current Good Manufacturing Practice (cGMP) guidelines for pre-clinical and clinical trial material.

Basic Information

Product Name	tert-Butyl ((1H-Indol-5-Yl)Methyl)Carbamate
CAS No.	267875-62-7
Molecular Formula	C14H18N2O2
Molecular Weight	246.31 g/mol
Synonyms	5-[[(tert-Butoxycarbonyl)amino]methyl]indole; N-Boc-5-(aminomethyl)indole; tert-Butyl N-[(1H-indol-5-yl)methyl]carbamate; Boc-5-Aminomethylindole; 1H-Indole-5-methanamine, N-[(1,1-dimethylethoxy)carbonyl]-; 5-(Boc-aminomethyl)indole; N-(tert-Butoxycarbonyl)-5-(aminomethyl)indole
EINECS	Contact for details

Quality Control

Our tert-Butyl ((1H-Indol-5-Yl)Methyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.