Description

4-Bromo-3-Methylthiophene-2-Carbonitrile is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it serves as a versatile precursor for constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the thiophene core for bioactivity.
• Material Science Precursor: Serves as a monomer or building block for conductive polymers, organic semiconductors, and non-linear optical (NLO) materials.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Utilized to create tagged molecules or probes for studying biological pathways and protein interactions.

Basic Information

Product Name	4-Bromo-3-Methylthiophene-2-Carbonitrile
CAS No.	266338-06-1
Molecular Formula	C6H4BrNS
Molecular Weight	202.07 g/mol
Synonyms	2-Cyano-4-bromo-3-methylthiophene; 3-Methyl-4-bromothiophene-2-carbonitrile; 4-Bromo-3-methyl-2-thiophenecarbonitrile; 2-Thiophenecarbonitrile, 4-bromo-3-methyl-; 4-Bromo-3-methylthiophene-2-carbonitrile; 266338-06-1; 4-Bromo-3-methyl-2-cyanothiophene
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Methylthiophene-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials such as strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.