Description

(6-2-[2-(4-Fluoro-Phenyl)-4-(4-Hydroxy-Phenylcarbamoyl)-5-Isopropyl-3-Phenyl-D5-Pyrrol-1-Yl]-Ethyl-2,2-Dimethyl-[1,3]-Dioxane-4-Yl)-Acetic Acid, tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex pyrrole-dioxane hybrid structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting specific biological pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of deuterated or fluorinated drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) for clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Deuterated Drug Development: Serves as a precursor for compounds where deuterium incorporation is used to modulate pharmacokinetic properties like metabolic stability.
• Fluorinated Compound Synthesis: The 4-fluoro-phenyl moiety makes it valuable for creating fluorinated analogs in drug discovery.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Reference Standard: Can be used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Item	Details
Product Name	(6-2-[2-(4-Fluoro-Phenyl)-4-(4-Hydroxy-Phenylcarbamoyl)-5-Isopropyl-3-Phenyl-D5-Pyrrol-1-Yl]-Ethyl-2,2-Dimethyl-[1,3]-Dioxane-4-Yl)-Acetic Acid, tert-Butyl Ester
CAS No.	265989-38-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	tert-Butyl (6-{2-[2-(4-fluorophenyl)-4-[(4-hydroxyphenyl)carbamoyl]-5-(propan-2-yl)-3-phenyl-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl)acetate (IUPAC); (6-{2-[2-(4-Fluorophenyl)-4-[(4-Hydroxyphenyl)carbamoyl]-5-Isopropyl-3-Phenyl-1H-Pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid tert-Butyl Ester; 265989-38-6; Deuterated Pyrrole-Dioxane Intermediate; 4-Fluoro-Phenyl D5-Pyrrole Derivative; tert-Butyl Dioxanylacetate Pyrrolecarboxamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and LC-MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Deuterium Incorporation (MS)	≥ 95 atom % D
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.