Description

6',7'-Dihydroxybergamottin is a bioactive furanocoumarin derivative primarily known for its role as a potent inhibitor of the cytochrome P450 enzyme CYP3A4. This property makes it a critical compound for research into drug-drug interactions, bioavailability, and metabolic pathways. It is an essential reference standard and raw material for the pharmaceutical, nutraceutical, and research sectors, particularly in studies involving grapefruit juice interactions and the development of metabolic modulators.

Application

• Pharmaceutical Research: Used as a reference standard in pharmacokinetic and drug metabolism studies to investigate CYP3A4-mediated interactions.
• Nutraceutical Development: Incorporated into research for formulating dietary supplements aimed at modulating drug absorption or metabolic rates.
• Clinical Biochemistry: Serves as a key inhibitor in in vitro assays to study enzyme kinetics and metabolic stability of new chemical entities.
• Academic Research: Utilized in university and institutional labs for fundamental research on furanocoumarin chemistry and biological activity.
• Quality Control: Acts as a high-purity analytical standard for the identification and quantification of bergamottin and related compounds in complex matrices.

Basic Information

Product Name	6',7'-Dihydroxybergamottin
CAS No.	264234-05-1
Molecular Formula	C21H22O6
Molecular Weight	370.40 g/mol
Synonyms	6',7'-Dihydroxybergamottin; DHB; 5-[(3,7-Dimethyl-2,6-octadienyl)oxy]-6,7-dihydroxypsoralen; 6',7'-Dihydroxy-5-geranyloxypsoralen; Bergamottin, 6',7'-dihydroxy-; Furanocoumarin DHB
EINECS	Contact for details

Quality Control

Our 6',7'-Dihydroxybergamottin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification via spectroscopic methods (IR, NMR, MS). We provide Certificates of Analysis (COA) with detailed specifications for trace impurities, residual solvents, and heavy metals, ensuring compliance with research and development grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.