Description

2-Chloro-6-(Trimethylsilyl)Pyridine is a versatile organosilicon-substituted pyridine derivative, serving as a key protected intermediate and directing group in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trimethylsilyl group, which facilitates selective functionalization at the 2-chloro position and can act as a traceless directing group or a protective moiety. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex heterocyclic scaffolds and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic-based therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the pyridine core is a common structural motif for biological activity.
• Ligand Precursor: Serves as a starting material for the preparation of specialized ligands used in catalysis, such as N-heterocyclic carbene (NHC) precursors or pyridine-based pincer ligands.
• Material Science: Employed in the synthesis of functionalized organic molecules for organic light-emitting diodes (OLEDs) and other electronic materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive chlorine atom.
• Directed Metalation: The trimethylsilyl group facilitates directed ortho-metalation (DoM), enabling precise functionalization of the pyridine ring for complex molecule assembly.

Basic Information

Product Name	2-Chloro-6-(Trimethylsilyl)Pyridine
CAS No.	263698-97-1
Molecular Formula	C8H12ClNSi
Molecular Weight	185.72 g/mol
Synonyms	2-Chloro-6-(trimethylsilyl)pyridine; 6-Chloro-2-(trimethylsilyl)pyridine; 2-Chloro-6-trimethylsilylpyridine; Pyridine, 2-chloro-6-(trimethylsilyl)-; 2-(Trimethylsilyl)-6-chloropyridine; 6-Chloro-2-pyridyltrimethylsilane
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Trimethylsilyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality commitment ensures the material meets the stringent requirements for research and development as well as scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using inert gas purging or desiccants.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.