Description

(+)-Calanolide D CAS NO 263351-94-6 is a high-purity, naturally-derived coumarin derivative known for its significant biological activity. This compound is of critical importance in pharmaceutical research and development, particularly as a lead structure for novel antiviral and anticancer agents. It is primarily sought by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery, medicinal chemistry, and the development of new therapeutic entities.

Application

• Pharmaceutical R&D: Serves as a key intermediate and reference standard in the discovery and synthesis of new antiviral drugs.
• Antiviral Agent Development: Investigated as a lead compound for activity against HIV and other retroviruses due to its non-nucleoside reverse transcriptase inhibitor (NNRTI) properties.
• Medicinal Chemistry Studies: Used in structure-activity relationship (SAR) studies to optimize the calanolide scaffold for enhanced potency and reduced toxicity.
• Biochemical Research: Employed as a tool compound in virology and cell biology to study viral replication mechanisms and host-cell interactions.
• Reference Standard: Utilized as an analytical standard in HPLC and LC-MS for quality control and quantification in research samples.
• Anticancer Research: Explored for potential cytotoxic and chemopreventive activities in various cancer cell line assays.

Basic Information

Product Name	(+)-Calanolide D
CAS No.	263351-94-6
Molecular Formula	C22H26O5
Molecular Weight	370.44 g/mol
Synonyms	(+)-Calanolide D; (10R,11S,12S)-10,11-trans-Dihydro-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-2H,6H-benzo[1,2-b:3,4-b']dipyran-2-one; NSC 675451; 12-Hydroxycalanolide D; Costatolide D
EINECS	Contact for details

Quality Control

Our (+)-Calanolide D is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.