Description

5-{[tert-Butyl(Dimethyl)Silyl]Oxy}-2-Methylpent-3-Yn-2-Ol is a specialized organosilicon-protected propargylic alcohol intermediate. This compound is valued for its role as a key synthetic building block in advanced organic synthesis, offering a protected hydroxyl group for selective deprotection strategies. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing acetylene and alcohol functionalities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, flavors, fragrances, and advanced materials.
• Academic & Industrial Research: A valuable reagent in methodology development, total synthesis projects, and catalysis studies.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group provides a stable, orthogonal protecting group for alcohols in multi-step syntheses.
• Cross-Coupling Reactions: The alkyne moiety makes it a suitable substrate for Sonogashira and other metal-catalyzed cross-coupling reactions.

Basic Information

Product Name	5-{[tert-Butyl(Dimethyl)Silyl]Oxy}-2-Methylpent-3-Yn-2-Ol
CAS No.	259880-64-3
Molecular Formula	C12H24O2Si
Molecular Weight	228.41 g/mol
Synonyms	2-Methyl-5-[(tert-butyldimethylsilyl)oxy]-3-pentyn-2-ol; 2-Methyl-5-((tert-butyldimethylsilyl)oxy)pent-3-yn-2-ol; 3-Pentyn-2-ol, 2-methyl-5-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; TBDMS ether of 2-Methyl-5-hydroxy-3-pentyn-2-ol; tert-Butyldimethyl(2-methyl-5-oxypent-3-yn-2-yloxy)silane
EINECS	Contact for details

Quality Control

Our production of 5-{[tert-Butyl(Dimethyl)Silyl]Oxy}-2-Methylpent-3-Yn-2-Ol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.