Description

1H-Indole-2-Carboxylic Acid, 6-Chloro-7-Fluoro-, Methyl Ester is a high-purity, halogenated indole derivative serving as a critical building block in advanced organic synthesis. Its value lies in its precise molecular architecture, which provides a versatile scaffold for constructing complex pharmacologically active molecules. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging the biological activity of the indole core.
• Chemical Biology Probe Synthesis: Employed to create labeled compounds and molecular probes for studying biological pathways and enzyme functions.
• Material Science Research: Acts as a monomer or functional additive in the development of specialty polymers and advanced organic electronic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects.

Basic Information

Product Name	1H-Indole-2-Carboxylic Acid, 6-Chloro-7-Fluoro-, Methyl Ester
CAS No.	259860-06-5
Molecular Formula	C11H7ClFNO2
Molecular Weight	239.63 g/mol
Synonyms	6-Chloro-7-fluoro-1H-indole-2-carboxylic acid methyl ester; Methyl 6-chloro-7-fluoro-1H-indole-2-carboxylate; 6-Chloro-7-fluoroindole-2-carboxylic acid methyl ester; 2-Carbomethoxy-6-chloro-7-fluoroindole; 259860-06-5; 6-Chloro-7-fluoro-2-indolecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 1H-Indole-2-Carboxylic Acid, 6-Chloro-7-Fluoro-, Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation, including HPLC chromatograms and NMR spectra, to verify identity and purity. Certificates of Analysis (COA) detailing all specification parameters are available for each lot and supplied with every order to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.