Description

Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6-D3 is a deuterium-labeled derivative of the classic 2,4-dinitrophenylhydrazone (DNPH) derivative of acetaldehyde. This compound is primarily valued as a high-purity analytical standard and a stable-isotope labeled reagent for precise quantitative analysis. It is essential for researchers and quality control laboratories in environmental monitoring, food safety, and industrial hygiene, where accurate measurement of carbonyl compounds like acetaldehyde is critical. The deuterium labeling provides an internal standard for advanced techniques like LC-MS and GC-MS, ensuring superior accuracy and reliability in trace-level detection.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical deuterated internal standard (IS) for the quantification of acetaldehyde and other aldehydes via GC-MS or LC-MS, minimizing matrix effects and improving data accuracy.
• Environmental Analysis: Used in the analysis of airborne carbonyls (e.g., in workplace air, automotive emissions, and atmospheric studies) following derivatization with DNPH, where labeled standards are required for reliable calibration.
• Food and Beverage Safety Testing: Enables precise measurement of acetaldehyde, a natural metabolite and potential contaminant, in products like alcoholic beverages, fruit juices, and packaged foods.
• Pharmaceutical Impurity Profiling: Employed in the identification and quantification of acetaldehyde as a genotoxic impurity or degradation product in active pharmaceutical ingredients (APIs) and drug products.
• Biomarker Research: Facilitates studies on oxidative stress and metabolic disorders by allowing accurate measurement of acetaldehyde-derived adducts in biological samples.
• Polymer and Material Science: Used to monitor acetaldehyde release from plastics, resins, and other synthetic materials during quality control and stability testing.
• Reference Material for Method Development: Acts as a certified reference material (CRM) for developing, validating, and accrediting analytical methods in compliance with ISO, FDA, and EPA guidelines.

Basic Information

Product Name	Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6-D3
CAS No.	259824-51-6
Molecular Formula	C8H4D3N4O4
Molecular Weight	212.17 g/mol
Synonyms	Acetaldehyde-D3 2,4-DNPH; [3,5,6-D3]-Acetaldehyde 2,4-Dinitrophenylhydrazone; Deuterated Acetaldehyde DNPH; Acetaldehyde (2,4-dinitrophenyl)hydrazone-3,5,6-d3; Acetaldehyde-d3 2,4-Dinitrophenylhydrazone; 2,4-DNPH Derivative of Acetaldehyde-d3; (E)-Acetaldehyde-3,5,6-d3 2-(2,4-dinitrophenyl)hydrazone; Isotopically Labeled Acetaldehyde DNPH
EINECS	Contact for details

Quality Control

Every batch of Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with specifications tailored for use as an analytical standard. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic purity (D-enrichment), identity confirmation (by IR and NMR), and impurity profile (by HPLC). Our quality protocols are designed to support compliance with GMP/GLP principles and relevant pharmacopeial guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is light-sensitive and should be handled accordingly to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to Orange Crystalline Powder
Identification (IR)	Conforms to Reference Spectrum
Identification (NMR)	Conforms to Structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.