Description

Dl-Leucine-4,5,5,5,6,6,6-D7 is a stable isotope-labeled analog of the essential branched-chain amino acid leucine, specifically deuterated at seven positions. This compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing, as the deuterium substitution minimizes metabolic interference while providing a distinct mass signature. It is primarily utilized by researchers and manufacturers in pharmaceutical development, metabolic studies, and analytical chemistry for use as an internal standard in mass spectrometry.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for the accurate quantification of leucine and related metabolites in complex biological matrices using LC-MS/MS and GC-MS.
• Metabolic Pathway Research: Used as a tracer to study protein synthesis, turnover, and branched-chain amino acid metabolism in nutritional, physiological, and disease-state investigations.
• Pharmaceutical Drug Development: Employed in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to track the fate of drug candidates containing leucine moieties.
• Stable Isotope Labeling: Serves as a building block for the synthesis of more complex deuterated peptides, proteins, or biochemical probes.
• Clinical Diagnostics: Potential use in developing high-precision diagnostic assays for metabolic disorders like maple syrup urine disease (MSUD).
• Nutritional Science: Applied in research to understand leucine's role in muscle protein synthesis and its impact on sports nutrition and aging.

Basic Information

Product Name	Dl-Leucine-4,5,5,5,6,6,6-D7
CAS No.	259225-40-6
Molecular Formula	C6H6D7NO2
Molecular Weight	138.20 g/mol (for deuterated form)
Synonyms	(±)-Leucine-d7; DL-Leucine-d7; 2-Amino-4-methyl-d7-pentanoic acid; 2-Amino-4-methylpentanoic-4,5,5,5,6,6,6-d7 acid; Leucine-4,5,5,5,6,6,6-d7; 4-Methyl-2-aminopentanoic-4,5,5,5,6,6,6-d7 acid; Deuterated DL-Leucine; [4,5,5,5,6,6,6-2H7]Leucine
EINECS	Contact for details

Quality Control

Our Dl-Leucine-4,5,5,5,6,6,6-D7 is produced and tested under strict quality systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % D), chemical purity, and identity confirmation. We adhere to cGMP principles for manufacturing and provide traceable documentation for research and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of water vapor. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % D)	≥ 98.0% (by MS)
Chemical Purity (Titration)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.