Description

6,7-Isoquinolinediol, 1-[(1S)-1,2-Dihydroxyethyl]-1,2,3,4-Tetrahydro- (9Ci) is a high-purity, chiral tetrahydroisoquinoline derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and synthetic intermediate for the development of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of potential drug candidates targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug discovery.
• Medicinal Chemistry Research: Used as a scaffold or precursor in structure-activity relationship (SAR) studies and lead optimization programs.
• Asymmetric Synthesis: Employed in stereoselective synthesis due to its defined (S)-configuration at the chiral center, enabling the construction of enantiomerically pure compounds.
• Biochemical Research: Potential use as a tool compound or inhibitor in enzymatic studies, given the structural similarity to natural isoquinoline alkaloids.
• Fine Chemical Production: Serves as a starting material for the manufacture of specialized fine chemicals and advanced materials requiring high chiral purity.

Basic Information

Product Name	6,7-Isoquinolinediol, 1-[(1S)-1,2-Dihydroxyethyl]-1,2,3,4-Tetrahydro- (9Ci)
CAS No.	259183-94-3
Molecular Formula	C11H15NO4
Molecular Weight	225.24 g/mol
Synonyms	(1S)-1-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol; 1-[(1S)-1,2-Dihydroxyethyl]-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline; (S)-1,2,3,4-Tetrahydro-1-(1,2-dihydroxyethyl)-6,7-isoquinolinediol; Tetrahydroisoquinoline derivative CAS 259183-94-3; Chiral tetrahydroisoquinoline diol; (S)-enantiomer of 1-(1,2-Dihydroxyethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 6,7-Isoquinolinediol, 1-[(1S)-1,2-Dihydroxyethyl]-1,2,3,4-Tetrahydro- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, with specifications tailored to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.