Description

Isopropyloxycarbonyloxymethyl Iodide is a specialized alkylating agent and a key protected intermediate in advanced organic synthesis. This compound matters for its role in introducing the isopropyloxycarbonyloxymethyl (POC) protecting group, which is crucial for the controlled functionalization of sensitive molecules, particularly in nucleoside and nucleotide chemistry. Pharmaceutical researchers and fine chemical manufacturers need this high-purity reagent to develop active pharmaceutical ingredients (APIs) and novel oligonucleotide therapeutics, where precise molecular assembly is paramount.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of nucleoside analogs and prodrugs for antiviral and anticancer therapies.
• Oligonucleotide Synthesis: Used to introduce protected phosphate or hydroxyl groups during solid-phase synthesis of DNA/RNA analogs.
• Prodrug Development: Serves as a reagent for creating bioreversible prodrug linkages to enhance drug bioavailability and targeting.
• Peptide Modification: Employed for the selective protection of specific amino acid side chains in complex peptide synthesis.
• Chemical Biology Research: A valuable tool for labeling and cross-linking studies in molecular probe development.
• Fine Chemical Synthesis: Used in multi-step organic synthesis for the controlled alkylation of alcohols, phenols, and amines.

Basic Information

Product Name	Isopropyloxycarbonyloxymethyl Iodide
CAS No.	258841-42-8
Molecular Formula	C6H9IO3
Molecular Weight	256.04 g/mol
Synonyms	POC-OMe-I; Isopropyl (Iodomethoxy)formate; (Isopropoxycarbonyloxy)methyl Iodide; 1-Methylethyl (Iodomethoxy)formate; Carbonochloridic Acid, (Iodomethoxy)-, 1-Methylethyl Ester; Iodomethyl Isopropyl Carbonate; Isopropyloxycarbonyloxymethyl Iodide; POC Protecting Group Reagent
EINECS	Contact for details

Quality Control

Our Isopropyloxycarbonyloxymethyl Iodide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a freezer to maintain stability and prevent degradation. The container should be kept in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.