Description

tert-Butyl 7-Bromo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, protected heterocyclic building block of significant value in advanced organic synthesis. Its core utility lies in serving as a versatile and reactive intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly for neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its reactive bromine and protected amine functionalities.
• Alkaloid Synthesis: Serves as a foundational building block for the synthesis of complex isoquinoline-based natural products and alkaloid analogs.
• Process Chemistry & Scale-up: Employed in route scouting and the development of robust, scalable manufacturing processes for target molecules.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	tert-Butyl 7-Bromo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	258515-65-0
Molecular Formula	C14H16BrNO2
Molecular Weight	310.19 g/mol
Synonyms	7-Bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 7-bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2-Boc-7-bromo-1,2,3,4-tetrahydroisoquinoline; 7-Bromo-2-N-Boc-1,2,3,4-tetrahydroisoquinoline; 7-Bromo-1,2,3,4-tetrahydroisoquinoline-2-N-tert-butoxycarbonyl; 7-Bromo-THIQ-2-Boc; Boc-7-Br-THIQ; 258515-65-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Bromo-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.