Description

1-(Thiophene-2-Carbonyl)-Pyrrolidine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique heterocyclic scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Protease Inhibitor Synthesis: Serves as a core structural component in the design and synthesis of protease inhibitor libraries for medicinal chemistry programs.
• Agrochemical Research: Used as a building block for developing novel crop protection agents and pesticides with specific biological activity.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating novel chiral ligands and catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring a functionalized pyrrolidine-thiophene hybrid structure.

Basic Information

Product Name	1-(Thiophene-2-Carbonyl)-Pyrrolidine-2-Carboxylic Acid
CAS No.	257946-35-3
Molecular Formula	C10H11NO3S
Molecular Weight	225.26 g/mol
Synonyms	2-Pyrrolidinecarboxylic acid, 1-(2-thienylcarbonyl)-; L-Proline, 1-(2-thienylcarbonyl)-; 1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid; 1-(2-Thienylcarbonyl)-L-proline; (S)-1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid; 1-(Thiophene-2-Carbonyl)-L-Proline; 257946-35-3; 1-(2-Thiophenecarbonyl)-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(Thiophene-2-Carbonyl)-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.