Description

1H-Benzimidazole, 2-Chloro-5-Iodo- CAS NO 256518-97-5 is a halogenated benzimidazole derivative, a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its dual halogen functionality, which provides distinct reactive sites for selective cross-coupling and substitution reactions, enabling the construction of complex molecular architectures. This high-purity intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel benzimidazole-based therapeutics, including potential kinase inhibitors, antiviral agents, and anticancer compounds.
• Agrochemical Research: Serves as a precursor in the synthesis of new fungicides, herbicides, and plant growth regulators that leverage the benzimidazole scaffold.
• Material Science: Used in the creation of organic semiconductors, ligands for catalysis, and specialty polymers where the halogenated benzimidazole unit imparts specific electronic or binding properties.
• Chemical Synthesis: Functions as a versatile building block in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution, enabling precise molecular diversification.
• Research & Development: Essential for academic and industrial research exploring new heterocyclic chemistry, medicinal chemistry libraries, and structure-activity relationship (SAR) studies.

Basic Information

Product Name	1H-Benzimidazole, 2-Chloro-5-Iodo-
CAS No.	256518-97-5
Molecular Formula	C7H4ClIN2
Molecular Weight	278.48 g/mol
Synonyms	2-Chloro-5-iodo-1H-benzimidazole; 5-Iodo-2-chlorobenzimidazole; 2-Chloro-5-iodobenzimidazole; 1H-Benzimidazole, 2-chloro-5-iodo-; Benzimidazole, 2-chloro-5-iodo-; 256518-97-5; 2-Cl-5-I-benzimidazole
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole, 2-Chloro-5-Iodo- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.