Description

3-Amino-4-Phenyl-5-(Trifluoromethyl)Thiophene is a high-value, multi-functional heterocyclic building block characterized by its unique thiophene core substituted with amino, phenyl, and trifluoromethyl groups. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the trifluoromethyl group is prized for its ability to modulate lipophilicity and metabolic stability. Industrial and research chemists in the pharmaceutical, agrochemical, and material science sectors need this specialized chemical to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group contributes to biological activity and environmental persistence.
• Organic Electronic Materials: Serves as a building block for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and photovoltaic cells.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Dye and Sensor Precursor: The electron-rich thiophene and amino functionalities make it a suitable starting material for developing fluorescent probes and chemosensors.
• Academic and R&D: Utilized in university and corporate research laboratories for methodological studies and the exploration of new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	3-Amino-4-Phenyl-5-(Trifluoromethyl)Thiophene
CAS No.	256427-77-7
Molecular Formula	C11H8F3NS
Molecular Weight	243.25 g/mol
Synonyms	3-Amino-4-phenyl-5-(trifluoromethyl)thiophene; 5-(Trifluoromethyl)-4-phenylthiophen-3-amine; 4-Phenyl-5-(trifluoromethyl)thiophen-3-amine; 3-Amino-4-phenyl-5-trifluoromethylthiophene; 256427-77-7; Thiophene, 3-amino-4-phenyl-5-(trifluoromethyl)-; 3-Amino-4-phenyl-alpha,alpha,α-trifluoro-3-thiophenemethanol (tautomer); 5-Trifluoromethyl-4-phenyl-3-aminothiophene
EINECS	Contact for details

Quality Control

Our 3-Amino-4-Phenyl-5-(Trifluoromethyl)Thiophene is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance assurance for your projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.